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Viagra has been used in approximately 15,000 men participating in clinical trials, and more than 8 million men worldwide (mainly in post-approval/post-marketing). The most common side effects when using Viagra are headache, indigestion, back pain, muscle pain, flushing, and stuffy or runny nose. These side effects reflect the ability of PDE5 inhibition on vasodilate (cause blood vessels to expand), and usually disappears after a few hours. Back pain and muscle pain may occur from 12 to 24 hours after taking the medication, and symptoms usually disappear within 48 hours.

In May 2005, the U.S. Food and medicines have been found that Viagra (along with other PDE5 inhibitors) was associated with vision disorders associated with NAION (non arteritic ischemic optic neuropathy front) in some patients taking these drugs in post-marketing (outside of clinical trials) setting. Most, but not all of these patients were the main anatomic or vascular risk factors for the development of NAION is not related to the use of PDE5, including: low cup to disk (full disk), more than 50 years, diabetes mellitus, hypertension, coronary disease, hyperlipidemia and smoking. Given the small number of NAION events with PDE5 use (less than 1 in 1 million), a large number of users of PDE5 inhibitors (millions) and the fact that this event is happening in the field of population, similar to those that do not In taking these drugs, the FDA concluded that they were unable to draw causal links, because these patients underlying vascular risk factors or anatomical defects. However, the label of the three PDE5 inhibitors was changed to prevent doctors to a possible partnership.

In October 2007, FDA announced that the labeling of all PDE5 inhibitors, including Viagra, requires a warning about the potential dangers of sudden hearing loss as a result of reports of deafness posts related to the use of inhibitors of PDE5.

Interaction

Since PDE5 inhibitors such as Viagra may cause temporary low blood pressure (hypotension), organic nitrates should not be taken for at least 48 hours after taking the last dose of Viagra. Using organic nitrates (such as the sex drug amyl nitrite) during this period may increase the risk of hypotension with life-threatening.

Because the people who took Viagra in the last 48 hours may not take organic nitrates alleviate angina (such as glyceryl trinitrate spray), these patients should seek immediate medical attention if they experience chest pain of angina. In the case of urgent medical care, doctors and medical staff should be notified of any recent doses of Viagra.