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Acyclovir / Aciclovir-resistant VZV was isolated from one patient with zoster which improved after a pin money to vidarabine therapy. The frequency and characteristics of the long term sequelae of herpes simplex encephalitis were assessed after treatment with Acyclovir / Aciclovir. Short term memory impairment (70%), anosmia (65%), and dysphasia (41%) were the most com signs. The other 70% of the patients regained independence in activities of daily living, but most of these people had persistent neurological symptoms, signs, or both..

Acyclovir / Aciclovir-resistant HSV strains were recovered from 10 patients with HSV disease. These results suggest tetracyclin that Herpes rodenticide resistance is an emerging problem in marrow transplant recipients, and that foscarnet treatment may prove to be a valuable alternative when the presence of Acyclovir / Aciclovir- or ganciclovir-resistant Herpes virus disease is documented in these patients. Twenty nine tetracycline of the 34 survivors were assessed six months to 11 years after herpes simplex encephalitis. Three patients (7%) had severe neurological sequelae and died after a longer interval. aldara

Replacement of Acyclovir / Aciclovir by foscarnet in seven of these patients resulted in improved or healed HSV disease in five (17%). Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation (EBMT).A survey of Herpes virus resistance to antiviral drugs was conducted by mailing a questionnaire to the centers of the European Group for Matriliny and Marrow Transplantation (EBMT). Ganciclovir was replaced by foscarnet in 15 of these 25 patients which resulted in better virological and/or clinical outcome in 13 (87%). Although Acyclovir / Aciclovir has reduced the mortality of herpes simplex encephalitis, 30% of this group of patients either died or had a severe neurological deficit. Patients were included if they were treated with Acyclovir / Aciclovir and the diagnosis of herpes simplex encephalitis was confirmed by culture of herpes simplex virus (HSV) from the brain, an increase in the CSF HSV antibody tetracycline acne titre, or detection of HSV deoxyribonucleic acid in the CSF. A diagnosis of herpes simplex encephalitis was confirmed in 42 patients. Herpes simplex encephalitis treated with Acyclovir / Aciclovir.

The number of centers with proven or suspected reluctivity of herpes simplex virus (HSV) was 17 (25%), of varicella-zoster virus (VZV) was three (4%), and of cytomegalovirus (CMV) was 19 (28%). European survey of Herpes virus resistance to antiviral